Are you on the hunt for a dish that perfectly marries flavor and comfort? Look no further than Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo. This delectable recipe packs a punch of bold Cajun spices alongside the creamy richness of a mozzarella Alfredo that will have your taste buds dancing. Imagine a plate filled with tender rotini pasta enveloped in a luscious sauce, topped with crispy, Cajun-seasoned chicken. It’s a culinary adventure that’s not only easy to prepare but also brings restaurant-quality flavors straight to your kitchen.
Comfort food has never tasted so good! This dish is not just about the flavor; it’s ideal for busy weeknight dinners or when you want to impress guests with minimal effort. Each forkful offers a delightful combination of textures — the chewiness of the pasta, the creaminess of the sauce, and the crispiness of the chicken. Plus, you can customize it based on your preferences. Whether you’re a fan of spiciness, prefer to tone it down, or want to add more vegetables, the options are endless!
Why You’ll Love This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo
- Bursting with Flavor: The Cajun seasoning adds a vibrant kick while perfectly complementing the creamy Alfredo sauce.
- Quick and Easy: Ready in just 40 minutes, this dish is perfect for busy weeknights or last-minute dinner plans.
- Customizable: Modify it to your taste — switch up the proteins, add veggies, or adjust the spice level.
- Impressive Presentation: It looks and tastes gourmet, making it great for entertaining guests.
- Comfort Food Classic: This dish is a fantastic way to indulge in creamy pasta that’s also hearty and satisfying.
Preparation Phase & Tools to Use
Before diving into the cooking process, preparation is key to ensuring a smooth experience in the kitchen. Start by gathering all your ingredients and tools. For this recipe, you’ll need a sturdy cutting board, a sharp knife, mixing bowls for your breading, and a large pot for boiling the pasta. A skillet is essential for cooking the Cajun chicken, and a saucepan will come in handy for preparing the creamy sauce.
It’s important to pound the chicken breasts to an even thickness for consistent cooking. This will prevent some parts from being overcooked while others remain undercooked. Have your measuring cups, spoons, and utensils handy to make the cooking process more efficient. Once you’re organized and ready, let’s cook this delicious pasta dish!

Ingredients
- 2 boneless skinless chicken breasts
- 2 tablespoons Cajun seasoning
- 1 teaspoon garlic powder
- 1/2 teaspoon paprika
- Salt and black pepper to taste
- 1/2 cup panko breadcrumbs
- 1/4 cup grated Parmesan
- 1 large egg
- 2 tablespoons olive oil
- 2 tablespoons unsalted butter
- 3 cloves garlic, minced
- 1 cup heavy cream
- 1 1/2 cups shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1/2 teaspoon Italian seasoning
- 1 tablespoon chopped parsley
- 12 oz rotini pasta
- Water and salt for boiling
Instructions
Step 1: Prepare the Chicken
Begin by placing your chicken breasts between two pieces of plastic wrap and pound them until they are of an even thickness, about ½ inch thick. This step is crucial for ensuring that they cook evenly. You can use a meat mallet or a rolling pin for this task. Once you have them flattened, season the chicken with salt and black pepper, and then rub the Cajun seasoning into the meat for a full flavor.
Step 2: Set Up the Breading Station
In a shallow dish, whisk the egg until it’s well combined. In another bowl, mix together the panko breadcrumbs, grated Parmesan, garlic powder, paprika, and a little salt and pepper. You’ll be making a classic breading station here—dipping the chicken first in the egg, then coating it in the breadcrumb mixture. This will create a flavorful, crispy crust when cooked.
Step 3: Cook the Chicken
Heat the olive oil in a large skillet over medium heat. Once the oil is hot, add the breaded chicken breasts. Cook for about 4–5 minutes per side or until they are golden brown and an internal temperature of 165°F is reached. After cooking, transfer the chicken to a cutting board and let it rest while you prepare the pasta and the sauce.
Step 4: Cook the Pasta
In a large pot, bring water to a boil and add salt. Cook the rotini pasta according to the package instructions, generally around 8–10 minutes until it reaches an al dente texture. Be sure to reserve half a cup of the pasta water before draining it to ensure a perfect sauce later on.
Step 5: Create the Alfredo Sauce
In a saucepan, melt the unsalted butter over medium heat. Add the minced garlic and sauté for about one minute until fragrant. Slowly pour in heavy cream, stirring to combine. Let this mixture simmer, and then gradually add the shredded mozzarella cheese and grated Parmesan cheese. Stir constantly to achieve a smooth and creamy sauce. Season with Italian seasoning, salt, and pepper according to your taste.
Step 6: Combine Everything
Now, it’s time to combine everything! Toss the drained rotini pasta in the creamy Alfredo sauce, adding reserved pasta water gradually until you achieve your desired consistency. The pasta should be well coated in the sauce. Lastly, slice the rested chicken and serve it beautifully arranged over the pasta. Don’t forget to garnish with freshly chopped parsley for that burst of color and freshness!

Variations
- Protein: You can swap the chicken for shrimp or even a grilled vegetable mix for a vegetarian option.
- Vegetables: Add in some spinach, bell peppers, or sun-dried tomatoes for extra flavor and nutrition.
- Spices: Adjust the spice level of the Cajun seasoning or add a dash of cayenne for extra heat.
Cooking Notes
- For more flavor, marinate the chicken in Cajun seasoning for a few hours before cooking.
- Ensure to constantly stir the cheese into the cream over low heat to prevent it from curdling.
- You can substitute the heavy cream with half-and-half for a lighter sauce.
Serving Suggestions
- Serve this dish with a side of garlic bread and a fresh green salad for a complete meal.
- A glass of white wine, like Sauvignon Blanc, pairs wonderfully with the spicy flavors of Cajun seasoning.
Tips
- Prep all your ingredients before starting to ensure a seamless cooking experience.
- If the sauce becomes too thick, stir in a little more reserved pasta water or cream to reach your preferred consistency.
- Leftovers can be stored in an airtight container in the fridge for up to 3 days; reheat on the stovetop with a splash of cream.
Prep Time, Cook Time, Total Time
- Prep Time: 15 minutes
- Cook Time: 25 minutes
- Total Time: 40 minutes
Nutritional Information
- Calories: 684 per serving
- Protein: 38g
- Sodium: 612mg
FAQs
Can I make the Cajun chicken ahead of time?
Absolutely! You can prepare and cook the chicken up to a day in advance. Just store it in the refrigerator and reheat when ready to serve.
Is there a substitute for heavy cream?
Yes, you can use half-and-half, whole milk, or a non-dairy alternative like cashew cream, but the texture and richness may vary.
Can I freeze leftovers?
While it’s best to enjoy this dish fresh, you can freeze the pasta and sauce separately. Reheat in the oven or microwave for best results.
What can I add to the sauce for extra flavor?
Consider adding some grated nutmeg, a splash of white wine, or even some diced sun-dried tomatoes to enhance the flavor profile of the sauce.
Conclusion
This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is truly a dish that stands out. Its combination of creamy textures, rich flavors, and heartwarming spices makes it a staple in any home kitchen. No matter the occasion, this recipe ensures satisfaction and the opportunity for delightful variations. Don’t hesitate to share your thoughts or any twists you put on this dish, and be sure to invite others to join in on this flavorful journey. Whether you stick to the classic recipe or explore new elements, one thing is certain: you’re going to love every single bite!
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Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo
- Total Time: 40 minutes
- Yield: 4 servings 1x
Description
This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo is truly a dish that stands out.
Ingredients
- 2 boneless skinless chicken breasts
- 2 tablespoons Cajun seasoning
- 1 teaspoon garlic powder
- 1/2 teaspoon paprika
- Salt and black pepper to taste
- 1/2 cup panko breadcrumbs
- 1/4 cup grated Parmesan
- 1 large egg
- 2 tablespoons olive oil
- 2 tablespoons unsalted butter
- 3 cloves garlic, minced
- 1 cup heavy cream
- 1 1/2 cups shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 1/2 teaspoon Italian seasoning
- 1 tablespoon chopped parsley
- 12 oz rotini pasta
- Water and salt for boiling
Instructions
- Begin by placing your chicken breasts between two pieces of plastic wrap and pound them until they are of an even thickness, about ½ inch thick. Season the chicken with salt and black pepper, and then rub the Cajun seasoning into the meat for a full flavor.
- In a shallow dish, whisk the egg until it’s well combined. In another bowl, mix together the panko breadcrumbs, grated Parmesan, garlic powder, paprika, and a little salt and pepper. Dip the chicken first in the egg, then coat it in the breadcrumb mixture.
- Heat the olive oil in a large skillet over medium heat. Once the oil is hot, add the breaded chicken breasts. Cook for about 4–5 minutes per side or until golden brown and an internal temperature of 165°F is reached.
- In a large pot, bring water to a boil and add salt. Cook the rotini pasta according to the package instructions, about 8–10 minutes. Reserve half a cup of the pasta water before draining it.
- In a saucepan, melt the unsalted butter over medium heat. Add the minced garlic and sauté for about one minute. Slowly pour in heavy cream, stirring to combine, and then add the shredded mozzarella cheese and grated Parmesan cheese. Stir to achieve a smooth sauce, seasoning with Italian seasoning, salt, and pepper to taste.
- Toss the drained rotini pasta in the creamy Alfredo sauce, adding reserved pasta water gradually until achieving desired consistency. Slice the rested chicken and serve it over the pasta, garnished with chopped parsley.
Notes
For more flavor, marinate the chicken in Cajun seasoning for a few hours before cooking. Ensure to constantly stir the cheese into the cream over low heat to prevent it from curdling.
- Prep Time: 15 minutes
- Cook Time: 25 minutes
- Category: Dinner
Nutrition
- Calories: 684 kcal
- Sodium: 612 mg
- Protein: 38 g